Journal: Frontiers in Neurology
Article Title: “Rogue” [DEspR+CD11b+] neutrophil subset correlates with severity in spontaneous intracerebral hemorrhage
doi: 10.3389/fneur.2022.935579
Figure Lengend Snippet: Spearman rank correlation analyses of three neutrophil-based markers with sICH severity: GCS-score, IPH-volume, and PHE-volume. Correlation of GCS-score [t-1] with (A) DEspR+CD11b+ neutrophil counts, K/μl (“rogue” Ns [t-1]). (B) NET-forming neutrophil counts, K/μl, (NET+Ns [t-1] and (C) neutrophil lymphocyte ratio (NLR). Correlation of IPH volume [t-1] with: (D) DEspR+CD11b+ neutrophil counts, K/μl (“rogue” Ns [t-1]), (E) NET-forming neutrophil counts, K/μl (NET+Ns [t-1], and (F) neutrophil-lymphocyte ratio (NLR). Correlation of PHE-volume [t-1] with (G) DEspR+CD11b+ neutrophil counts, K/μl (“rogue” Ns [t-1]), (H) NET-forming neutrophil counts, K/μl (NET+Ns [t-1]), and (I) neutrophil-lymphocyte ratio (NLR). All measurements were obtained on the same day ± 1-day [t-1] as the day of flow cytometry analysis; red • symbols represent sICH-subject nonsurvivors; gray • symbols mark values for sICH-subject survivors; r , Spearman rank correlation coefficient; p B , p -value with Bonferroni correction. ns, not significant.
Article Snippet: For this pilot observational study, correlations were calculated using the Spearman Rank Order correlation test (GraphPad PRISM version 9.3), and power calculations were determined using the SigmaPlot 11.0 software.
Techniques: Flow Cytometry